Nitsche, who won a WSOP bracelet this summer, defeated English pro Jerome Bradpiece to take down the first-place prize of $206,153.
WPT South Africa began five days ago with Chris Moneymaker, Joe Cada, Liv Boeree, Melanie Weisner and McLean Karr all paying the $3,600 entry fee.
The big-name pros were all snuffed prior to the money, however, which began with 27 players remaining.
Nitsche, on the other hand, was a force from day one in this event as he took the overall chip lead on Day 1a.
The German pro was amongst the chip leaders for the majority of the tournament and entered the final table as the overwhelming chip leader with 2.9 million chips.
Bradpiece a Thorn in Nitsche’s Side
Jerome Bradpiece was Nitsche’s main rival at the final table as the English pro busted two players early and then doubled to over two million chips against Nitsche.
Nitsche did take the chip lead into heads-up play, however, with 4.05 million to Bradpiece’s 2.8 million.
In the final hand of the tournament Nitsche moved all-in with A♣ 4♣ and Bradpiece called for his entire short stack with J♣ T♣.
The board bricked and Nitsche became the new South African champion while Bradpiece, who finished fifth in the €5k PLO event at this year's WSOPE, locked up $121,477 for coming in second place.
Interestingly Nitsche came in sixth in the other WPT event that takes place in Africa, WPT Marrakech, back in 2010. Fellow German Sebastian Homann went on to win that tournament for $341,798.
Perhaps more notably Nitsche won one of the massive $1,000 No-Limit Hold'em events at the WSOP this summer for $654,797.
With WSOP and WPT wins in the bag, Nitsche could complete poker's triple crown by winning a European Poker Tour event.
Here are the complete final table payouts for WPT South Africa:
1. Dominik Nitsche - $206,153 2. Jerome Bradpiece - $121,477 3. William Ross - $80,985 4. Wesley Weigand - $56,321 5. Jason Strauss - $41,965 6. Andrew Anthony - $32,394Visit www.pokerlistings.com